Please use this identifier to cite or link to this item: https://physrep.ff.bg.ac.rs/handle/123456789/1182
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dc.contributor.authorKlein, Eric Een_US
dc.contributor.authorVićić, Milošen_US
dc.contributor.authorMa, Chang-Mingen_US
dc.contributor.authorLow, Daniel Aen_US
dc.contributor.authorDrzymala, Robert Een_US
dc.date.accessioned2022-07-12T18:35:35Z-
dc.date.available2022-07-12T18:35:35Z-
dc.date.issued2008-03-07-
dc.identifier.issn0031-9155en
dc.identifier.urihttps://physrep.ff.bg.ac.rs/handle/123456789/1182-
dc.description.abstractTreating shallow tumors with a homogeneous dose while simultaneously minimizing the dose to distal critical organs remains a challenge in radiotherapy. One promising approach is modulated electron radiotherapy (MERT). Due to the scattering properties of electron beams, the commercially provided secondary and tertiary photon collimation systems are not conducive for electron beam delivery when standard source-to-surface distances are used. Also, commercial treatment planning systems may not accurately model electron-beam dose distributions when collimated without the standard applicators. However, by using the photon multileaf collimators (MLCs) to create segments to modulate electron beams, the quality of superficial tumor dose distributions may improve substantially. The purpose of this study is to develop and evaluate calculations for the narrow segments needed to modulate megavoltage electron beams using photon beam multileaf collimators. Modulated electron radiotherapy (MERT) will be performed with a conventional linear accelerator equipped with a 120 leaf MLC for 6-20 MeV electron beam energies. To provide a sharp penumbra, segments were delivered with short SSDs (70-85 cm). Segment widths (SW) ranging from 1 to 10 cm were configured for delivery and planning, using BEAMnrc Monte Carlo (MC) code, and the DOSXYZnrc MC dose calculations. Calculations were performed with voxel size of 0.2 x 0.2 x 0.1 cm3. Dosimetry validation was performed using radiographic film and micro- or parallel-plate chambers. Calculated and measured data were compared using technical computing software. Beam sharpness (penumbra) degraded with decreasing incident beam energy and field size (FS), and increasing SSD. A 70 cm SSD was found to be optimal. The PDD decreased significantly with decreasing FS. The comparisons demonstrated excellent agreement for calculations and measurements within 3%, 1 mm. This study shows that accurate calculations for MERT as delivered with existing photon MLC are feasible and allows the opportunity to take advantage of the dynamic leaf motion capabilities and control systems, to provide conformal dose distributions.en
dc.language.isoenen
dc.relation.ispartofPhysics in medicine and biologyen
dc.subject.meshElectronsen
dc.subject.meshPhotonsen
dc.subject.meshRadiotherapy, Conformalen
dc.titleValidation of calculations for electrons modulated with conventional photon multileaf collimatorsen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1088/0031-9155/53/5/003-
dc.identifier.pmid18296757-
dc.identifier.scopus2-s2.0-42649091439-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/42649091439-
dc.relation.issue5en
dc.relation.volume53en
dc.relation.firstpage1183-208en
dc.relation.lastpage1208en
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
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