Please use this identifier to cite or link to this item: https://physrep.ff.bg.ac.rs/handle/123456789/1203
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dc.contributor.authorStojadinovic, Strahinjaen_US
dc.contributor.authorLow, Daniel Aen_US
dc.contributor.authorVićić, Milošen_US
dc.contributor.authorMutic, Sasaen_US
dc.contributor.authorDeasy, Joseph Oen_US
dc.contributor.authorHope, Andrew Jen_US
dc.contributor.authorParikh, Parag Jen_US
dc.contributor.authorGrigsby, Perry Wen_US
dc.date.accessioned2022-07-12T18:35:38Z-
dc.date.available2022-07-12T18:35:38Z-
dc.date.issued2006-10-
dc.identifier.issn0094-2405en
dc.identifier.urihttps://physrep.ff.bg.ac.rs/handle/123456789/1203-
dc.description.abstractMicroradiation therapy (microRT) systems are being designed to provide conformal radiation therapy to small animals enabling quantitative radiation response evaluation. We used a Monte Carlo approach to estimate the radiation dose distributions from proposed blueprints and developed a beam model to aid in the microRT system design process. This process was applied to a prototype irradiator that uses a small (3 mm long and 3 mm in diameter), cylindrical, high-activity 192Ir source delivering the radiation beam using custom-fabricated tungsten collimators. The BEAMnrc Monte Carlo code was used to simulate dose distributions from these prototype collimators. Simulations were performed at three source-to-surface distances (50, 60, and 70 mm), and with five circular field sizes (5, 7.5, 10, 12.5, and 15 mm). A dose to a 50 X 50 X 50 mm3 water phantom with 1 X 1 X 1 mm3 voxel spacing was computed. A multiparameter dose calculation algorithm was developed to efficiently and accurately calculate doses for treatment planning exercises. The parametrization was selected so that the parameters varied smoothly as a function of depth, source-to-surface distance, and field size, allowing interpolation for geometries that were not simulated using the Monte Carlo simulation. Direct comparison of the model with the Monte Carlo simulations showed that the variations were within 5% error for field sizes larger than 10 mm, and up to 10% for smaller field sizes.en
dc.language.isoenen
dc.relation.ispartofMedical physicsen
dc.subject3D dose distributionen
dc.subjectBeam modelen
dc.subjectMicroRTen
dc.subjectMonte Carlo simulationsen
dc.subjectSmall animal radiation therapyen
dc.subject.meshRadiotherapy Planning, Computer-Assisteden
dc.subject.meshRadiotherapy, Conformalen
dc.titleProgress toward a microradiation therapy small animal conformal irradiatoren_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1118/1.2349693-
dc.identifier.pmid17089848-
dc.identifier.scopus2-s2.0-33749419162-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/33749419162-
dc.relation.issue10en
dc.relation.volume33en
dc.relation.firstpage3834-45en
dc.relation.lastpage3845en
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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