Please use this identifier to cite or link to this item: https://physrep.ff.bg.ac.rs/handle/123456789/469
Title: Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe<inf>3</inf>O<inf>4</inf> Magnetic Nanoparticles
Authors: Radović, Magdalena
Mirković, Marija
Nikolić, Aleksandar S.
Kuraica, Milorad 
Iskrenović, Predrag
Milanović, Zorana
Vranješ-Đurić, Sanja
Perić, Marko
Keywords: 177 Lu labeling;Hyperthermia;Laser transmittance;Magnetic nanoparticles;Non-alternating magnetic field
Issue Date: 1-Nov-2021
Journal: Journal of Inorganic and Organometallic Polymers and Materials
Abstract: 
Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability and biocompatibility which enables their biomedical application. The magnetic hyperthermia efficiency of phosphates (IDP and IHP) and phosphonates (MDP and HEDP) coated Fe3O4 magnetic nanoparticles (MNPs) were evaluated in an alternating magnetic field. For a deeper understanding of hyperthermia, the behavior of investigated MNPs in the non-alternating magnetic field was monitored by measuring the transparency of the sample. To investigate their theranostic potential coated Fe3O4-MNPs were radiolabeled with radionuclide 177Lu. Phosphate coated MNPs were radiolabeled in high radiolabeling yield (> 99%) while phosphonate coated MNPs reached maximum radiolabeling yield of 78%. Regardless lower radiolabeling yield both radiolabeled phosphonate MNPs may be further purified reaching radiochemical purity of more than 95%. In vitro stabile radiolabeled nanoparticles in saline and HSA were obtained. The high heating ability of phosphates and phosphonates coated MNPs as sine qua non for efficient in vivo hyperthermia treatment and satisfactory radiolabeling yield justifies their further research in order to develop new theranostic agents.
URI: https://physrep.ff.bg.ac.rs/handle/123456789/469
ISSN: 1574-1443
DOI: 10.1007/s10904-021-02059-1
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